ABC multidrug transporters in schistosomes and other parasitic flatworms
نویسندگان
چکیده
منابع مشابه
Multidrug resistance and ABC transporters in parasitic protozoa.
Drug resistance is an important problem in parasitic protozoa. We review here the role of ABC transporters in drug resistance in parasites. We have concentrated on gene and gene products for which there is a strong evidence for their role in resistance.
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Praziquantel (PZQ) is essentially the only drug currently available for treatment and control of schistosomiasis, a disease affecting hundreds of millions worldwide. Though highly effective overall, PZQ has limitations, most notably its significant lack of activity against immature schistosomes. Furthermore, the availability of only a single drug for a disease of this magnitude makes reports of...
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Schistosomiasis, which is caused by helminth trematode blood flukes of the genus Schistosoma, is a serious health and economic problem in tropical areas, and the second most prevalent parasitic disease after malaria. Currently, there is no effective vaccine available and treatment is entirely dependent on a single drug, praziquantel (PZQ), raising a significant potential public health threat du...
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ژورنال
عنوان ژورنال: Parasitology International
سال: 2013
ISSN: 1383-5769
DOI: 10.1016/j.parint.2013.02.006